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The Effect of Excess Weight Gain with Intensive Diabetes Treatment on CVD

Intensive treatment of type 1 diabetes reduces complications associated with the disease but also causes weight gain….

The study was conducted to determine if weight gain associated with intensive treatment of type 1 diabetes can lead to atherosclerotic disease. During an Epidemiology of Diabetes Interventions and Complications (EDIC) Study, type 1 diabetes patients were assigned to two treatment groups: intensive or conventional.

Subjects who gained excess weight had a greater body mass index or BMI, along with a larger waist circumference, and also required more insulin in the treatment of their diabetes. The subjects in the excess weight gain category also had a greater likelihood of having larger coronary artery calcium scores.

More data was collected on these subjects and found that the subjects who met the criteria for metabolic syndrome in regards to waist circumference and blood pressure had a greater intima-media thickness. Also, the subjects who fell under the high density lipoprotein criteria also had greater coronary artery calcium scores at follow up.

Patients who received intensive treatment were found to have an increased frequency of family history of diabetes, hyperlipidemia, and hypertension. The same was not found with the subjects who received conventional treatment.

In conclusion, the researchers of this study found that excess weight gain can be associated with maintained increases in insulin resistance, dyslipidemia, blood pressure, obesity and extensive atherosclerosis during these trials.

Jonathan Q. Purnell, Bernard Zinman, John D. Brunzell for the DCCT/EDIC Research Group Circulation. 2013; 127(2): p. 180-187 http://circ.ahajournals.org/cgi/content/abstract/127/2/180?ct=ct