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The Effect of Dapagliflozin on Renal Disease Progression

Nov 28, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Abdullah Al-Ajmi, PharmD Candidate, Skaggs School of Pharmacy and Pharmaceutical Sciences

Chronic kidney disease (CKD) affects around 700million people worldwide and is linked to a decreased quality of life and increased mortality rates. To date, only angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are proven to have renal protective outcomes in patients with type 2 diabetes mellitus (T2DM). Favorable effects were also reported with sodium-glucose cotransporter 2 (SGLT2) inhibitors in cardiovascular and renal outcomes. In the CREDENCE trial, the results showed that long term use of canagliflozin provides cardiovascular and renal protection in patients with T2DM. The exact mechanism is not well known, but it is suggested that the overall effect of SGLT2-inhibitors on sodium and glucose excretion may reduce intraglomerular pressure, leading to renal preservation in patients with CKD.  

This study aimed to assess the long-term effect of dapagliflozin in patients with CKD, regardless of whether they have T2DM or not....


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