Monday , December 18 2017
Home / Resources / Articles / The Debate about Diabetes’ Effects on the Diaphragm Continues

The Debate about Diabetes’ Effects on the Diaphragm Continues

New study suggests respiratory research in diabetes patients needs to be done differently in future…

Diabetes has been known to cause respiratory problems in patients. Often aerobic and endurance training is encouraged to counteract this issue. Current respiratory research in diabetes patients has focused on diaphragm muscles and other skeletal muscles as a grouping due to their similarities.

New findings, however, contradict this previous research. Research published recently in the Journal of Applied Physiology evaluated rats predisposed to obesity and insulin resistance and both endurance and interval treadmill training over the course of several weeks.

During the exercise training, researchers evaluated which muscle genes were turned on or off in the rats. Contrary to most research, they found that smooth muscles in the arteries of the diaphragm and skeletal muscle adapt to exercise differently.

These findings suggest that the gene alterations in obese, diabetic patients may impact the adaptations of the diaphragm and skeletal muscles differently.

Researchers in this study call for future research evaluating these two muscles as separate systems in patients with diabetes and obesity. Perhaps, evaluating these muscle groups independently of one another can shed more light on the respiratory problems associated with diabetes.

Furthermore, understanding how these muscle groups adapt differently can help us better design exercise regimens that are more well-suited for these patients.

Practice Pearls:

  • Current respiratory research in diabetes patients has been focusing on the diaphragm and smooth skeletal muscle as one in the same due to their shared similarities.
  • In testing rats with both obesity and insulin resistance for an endurance and interval training, researchers found that the genetic alterations and adaptations of the diaphragm and skeletal muscles are different.
  • Researchers call for future research to evaluate the diaphragm and skeletal muscles as two different muscle groups in obese patients with diabetes.

Laughlin, Maurice Harold, Jaume Padilla, Nathan T. Jenkins, et al. “Exercise Training Causes Differential Changes in Gene Expression in Diaphragm Arteries and 2A Arterioles of Obese Rats.” Journal of Applied Physiology J Appl Physiol (2015). Web. 28 Aug. 2015.