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Strong Link Identified Between T2DM and Parkinson’s Disease

Jun 13, 2018
 

Findings in large cohort study based in the United Kingdom

WEDNESDAY, June 13, 2018 (HealthDay News) — There is an increased rate of subsequent Parkinson’s disease among individuals diagnosed with type 2 diabetes mellitus (T2DM), according to a study published online June 13 in Neurology.

Eduardo De Pablo-Fernandez, M.D., from the University College London Institute of Neurology, and colleagues used linked English national Hospital Episode Statistics and mortality data (1999 to 2011) to investigate the association between T2DM and subsequent Parkinson’s disease. More than two million individuals were in the T2DM cohort and more than six million in the control cohort.

The researchers observed significantly elevated rates of Parkinson’s disease following T2DM (hazard ratio, 1.32; P < 0.001). The increased risk was greater in those with complicated T2DM (hazard ratio, 1.49) and among younger individuals (hazard ratio, 3.81 in age group 25 to 44 years).

“Our study examined data on a large portion of the English population and found a strong link between these two seemingly different diseases,” a coauthor said in a statement. “Whether it is genetics that may play a role in the development of these diseases or they have similar pathways to development needs to be investigated further.”

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