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The Value of the Nitric Oxide Pathway and its Importance in African-American Patients with Heart Failure

Talking to Patients

Studies in heart failure and hypertension have shown that people who identify themselves as black may have a less active renin-angiotensin system and a lower bioavailability of nitric oxide. The A-HeFT study was conducted to determine if a fixed dose of isosorbide dinitrate (ISDN) and hydralazine would provide additional benefit in black patients with heart failure.

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Discontinuation of TZD Reduces Fracture Rates

Managing stress

Thiazolidinediones (TZDs), rosiglitazone and pioglitazone, have been shown to increase fracture risk in women after a year of TZD use; however, there has been little data available on the effects of the discontinuation of TZD. This longitudinal observational cohort study used data from an ancillary study of skeletal health within …

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Finerenone Improves Albuminuria in Diabetic Nephropathy Patients

Mineralocorticoid receptor antagonists (MRAs) are often used with a renin-angiotensin system (RAS) blocker to further reduce proteinuria in patients with CKD. However, eplerenone and spironolactone increase the risk of hyperkalemia in these patients. Finerenone (BAY94-8862) is a new nonsteroidal MRA that has better receptor selectivity than spironolactone, associating with lower …

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Diagnosing Gastroparesis – Part 3

Diabetes Solution Richard K. Bernstein, MD, FACE, FACN, FACCWS Part 3 Chapter 22 Gastroparesis Efforts at diagnosis are usually unnecessary if there is no reason to suspect the presence of gastroparesis. So first we must have an index of suspicion. If, at the initial history-taking interview with your physician, you …

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Diagnosing Gastroparesis – Part 4

Diabetes Solution Richard K. Bernstein, MD, FACE, FACN, FACCWS Part 4 Chapter 22 Gastroparesis It is worth noting that gastroparesis can be cured by extended periods of normal blood sugars. I’ve seen several relatively mild cases where special treatment was terminated after about 1 year, and blood sugar profiles remained …

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Diagnosing Gastroparesis – Part 5

Diabetes Solution Richard K. Bernstein, MD, FACE, FACN, FACCWS Part 5 Chapter 22 Gastroparesis Super Papaya Enzyme Plus has been praised by many of my patients for its rapid relief of some of the physical symptoms of gastroparesis— bloating and belching, for example. Some claim that it also helps to …

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