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Skipping Meals Increases Abdominal Fat and Increases Diabetes Risk

Eating smaller meals is a way to lose weight, but skipping meals altogether has been linked to increased abdominal fat…

“This does support the notion that small meals throughout the day can be helpful for weight loss, though that may not be practical for many people,” said Martha Belury, professor of human nutrition at Ohio State University, in a press release.

Mice put on a restricted diet and mice who were free to eat all day both lost weight in a new study, but the mice on the restricted diet consumed all their food at once and then effectively fasted all day. The mice on the restricted diet showed signs of extra fat around the middle of their bodies — similar to human belly fat.

The extra belly fat was credited by researchers to a confused metabolic process in the mice’s bodies.

After eating, the pancreas produces insulin to help process glucose from food. At times when there is too much insulin in the blood, the liver produces glucose to balance the system. Because the mice were gorging themselves on food, their pancreases did not produce enough insulin to process glucose from their food. The result was extra glucose in the system that was eventually stored as fat.

Belury added that, “Under conditions when the liver is not stimulated by insulin, increased glucose output from the liver means the liver isn’t responding to signals telling it to shut down glucose production.” “These mice don’t have type 2 diabetes yet, but they’re not responding to insulin anymore and that state of insulin resistance is referred to as prediabetes.”

Practice Pearls:

  • Mice put on a restricted diet and mice who were free to eat all day both lost weight.
  • The mice on the restricted diet consumed all their food at once and then effectively fasted all day.
  • The mice on the restricted diet showed signs of extra fat around the middle of their bodies — similar to human belly fat.

Kara L. Kliewer. Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice. The Journal of Nutritional Biochemistry. Pub online March 14, 2015 DOI: http://dx.doi.org/10.1016/j.jnutbio.2015.01.010