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Saccharin May Impair Glucose Metabolism

Researchers from the Weizmann Institute of Science in Israel found that differences in gut microbes may explain why some people can handle artificial sweeteners just fine while in others the sweeteners lead to glucose intolerance. In studies in mice and people, researchers examined the interaction between gut microbes and consumption of the sweeteners aspartame, sucralose and saccharine. Depending on the types of microbes they had in their intestines, some people and mice saw a two- to fourfold increase in blood sugars after consuming the artificial sweeteners for a short time. Note: Results from this study were far from conclusive and based on a small sample size of human subjects and only using the highest allowable dosage of saccharin. Nature Sept 2014