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Resveratrol Has No Metabolic Benefit for Non-Obese Women

Resveratrol supplementation does not improve plasma lipids or insulin sensitivity in non-obese women, nor does it affect its putative targets in fat or muscle….

Jun Yoshino, M.D., Ph.D., from Washington University in St. Louis, and colleagues conducted a randomized, double-blind, placebo-controlled trial in which 45 non-obese, postmenopausal women with normal glucose tolerance were allocated to receive 12 weeks of resveratrol supplementation (75 mg/day), 12 weeks of placebo, or calorie restriction to achieve a 5 percent weight loss within 12 weeks (15 women each). The metabolic effects were evaluated using a two-stage hyperinsulinemic-euglycemic clamp procedure performed in conjunction with stable isotopically labeled tracer infusions.

Resveratrol has been reported to improve metabolic function in metabolically abnormal rodents and humans, but it has not been studied in nonobese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in nonobese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation increased plasma resveratrol concentration, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically labeled tracer infusions, demonstrated that resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity. Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, SIRT1, NAMPT, and PPARGC1A, in either skeletal muscle or adipose tissue. These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in nonobese, postmenopausal women with normal glucose tolerance.

The researchers found that resveratrol supplementation correlated with increased plasma resveratrol concentration, but it did not alter body composition, resting metabolic rate, plasma lipids, or inflammatory markers. Resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity based on results from the clamp procedure. In skeletal muscle and adipose tissue, resveratrol had no effect on its postulated molecular targets, including AMPK, SIRT1, NAMPT, and PPARGC1A.

"These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in non-obese, postmenopausal women with normal glucose tolerance," the authors write.

Practice Pearls:
  • Resveratrol supplementation does not improve plasma lipids in nonobese women
  • Resveratrol does not improve insulin sensitivity in nonobese women
  • Resveratrol does not affect its putative targets in fat or muscle in nonobese women

Cell Metabolism,25 October 2012