Lifestyle Intervention Remains the Most Effective and Safe Method for Diabetes Prevention. Even thought the Dream Study showed that rosiglitizone can reduce the risk for diabetes by 62%, it also increased the risk of heart failure by 5-fold compared with placebo. Highlights from ADA and EASD meetings 2006 showed that Lifestyle intervention still remains the most effective and safe methods for diabetes prevention. The results of the DREAM study presented at the annual meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, 9-13 September, showed that ramipril and rosiglitazone are either ineffective or unsafe for preventing diabetes.
Ramipril did not significantly reduce the new cases of diabetes compared with placebo, while rosiglitazone reduced the risk of new diabetes by 62%, but at the expense of significantly more cases of heart failure (5-fold increase in incidence) compared with placebo. Link to the DREAM website