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Question 859

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This class of drugs is typically reserved for individuals with type 1 diabetes or others receiving intensive insulin therapy. It inhibits glucagon secretion and slows gastric emptying: 1. Amylin mimetics 2. GLP-1 receptor agonists 3. DPP-4 inhibitors 4. SGLT-2 inhibitors Did you get it right? Follow the link to find out!

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When Losing Weight, Warn ’em!

I work in obesity medicine. As many of us know, losing weight isn't the problem for most, but weight regain is. As the saying goes for many, you can't be rich enough or thin enough. Many of our patients come in with unrealistic goals regarding their weight loss, and don't give themselves enough credit for the weight they have lost. Many, for many reasons, regain.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #49: Biosynthesis, secretion, and action of glucagon Part 3 of 4

Control of glucagon release: There is considerable evidence that the control of glucagon secretion is multifactorial and involves direct effects of nutrients on alpha-cell stimulus-secretion coupling as well as paracrine regulation by insulin, somatostatin and, possibly, other mediators such as zinc, γ-amino-butyric acid (GABA) or glutamate. Glucagon secretion is also regulated by circulating hormones and the autonomic nervous system.

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