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Physical Activity Is Only One Part of the Equation


As an exercise physiologist, I first and foremost focus on the physical activity part for management of blood glucose levels, often stating that being active will increase insulin action, lower blood glucose levels, and make diabetes management easier. In reality, not all of those benefits are fully evident in many cases. In fact, they usually cannot be counted on unless you take into account myriad other factors that can have an equally—if not more—dramatic effect on blood glucose management.

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Question #871

Test Your Knowledge

Hypoglycemia is a potential side effect of which of the following classes of drugs: 1) Insulins 2) Sulfonylureas 3) Meglitinides 4) Amylin mimetics 5) All of the above Follow the link to see the right answer!

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Life Happens to Our Patients Too. Be Understanding.

Diabetes test in the office

Woman, type 1 diabetes, 63 years of age. Well-educated diabetes wise. Reached out to me saying: "HELP!! Normally I take 10 units of Toujeo at 9 pm. I did that last night. This morning I meant to take an additional 2 units because I'm not getting any exercise due to a knee injury. By mistake I took my usual dose of 10 units." Before I read the rest of her email, I thought, I know her. She knows what to do. She wears a CGM, she’ll be watching that. Then I read on...

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #60: Mechanisms of Insulin Signal Transduction Part 4 of 8


PI-3 kinase pathways: regulation of metabolism and gene expression: Signal transduction for insulin’s metabolic effects also diverges from insulin receptor substrate proteins and proceeds via the PI-3 kinase pathway. The first committed step involves type 1A PI-3 kinase, a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit. In quiescent cells, the regulatory subunit maintains a state of low activity for the catalytic subunit.

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