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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #81: Insulin Actions In Vivo: Glucose Metabolism Part 8 of 9

Glucose phosphorylation and glucose transport are tightly coupled phenomena. Isoenzymes of HK (HK-I to HK-IV) catalyze the first committed intracellular step of glucose metabolism, the conversion of glucose to G-6-P. HK-I, HK-II, HK-III are single-chain peptides that have a number of properties in common, including a very high affinity for glucose and product inhibition by G-6-P.

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