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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #80: Insulin Actions In Vivo: Glucose Metabolism Part 6 of 9

Intravenous glucose: In the presence of euglycemia, insulin displays a potent suppressive action on hepatic glucose production, such that portal insulin concentrations of less than 100 mU L−1 abolish glucose entry into the circulation. Figure 14.7 shows a typical time course for endogenous glucose production following an acute increase in plasma insulin to levels of 60 – 70 mU L−1 in a healthy subject.

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GLP-1 and Basal Insulin

Test Your Knowledge

Which of the following GLP-1 agonists is not currently approved for use with basal insulin? A. Exenatide (Byetta) B. Dulaglutide (Trulicity) C. Albiglutide (Tanzeum) D. Liraglutide (Victoza) E. None of the above Did you get it right? Follow the link to find out!

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Current Interview: Dr. Ralph Defronzo on The Effectiveness of Triple Therapy

Dr. Ralph Defronzo, MD, speaks about the current variability of diabetes medication as well as their effectiveness but lack of affordability, and he places a special emphasis on the effectiveness of triple therapy in the treatment of diabetes. Dr. Defronzo is a Professor of Medicine and Chief of the Diabetes Division at the University of Texas Health Diabetes Center in San Antonia, Texas. Dr. Defronzo is also Deputy Director of the Texas Diabetes Institute.

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