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In summary, postbinding defects in insulin action primarily are responsible for the insulin resistance in T2DM. Diminished insulin binding, when present, is modest and secondary to downregulation of the insulin receptor by chronic hyperinsulinemia. In type 2 diabetic patients with overt fasting hyperglycemia, a number of postbinding defects have been demonstrated, including reduced insulin receptor tyrosine kinase activity, insulin signal transduction abnormalities, decreased glucose transport, diminished glucose phosphorylation, and impaired glycogen synthase activity. The glycolytic/glucose oxidative pathway is largely intact and, when defects are observed, they appear to be acquired secondary to enhanced FFA/lipid oxidation. From the quantitative standpoint, impaired glycogen synthesis represents the major pathway responsible for the insulin resistance in T2DM, and is present long before the onset of overt diabetes, that is, in normal glucose-tolerant, insulin-resistant prediabetic subjects and in individuals with IGT. The impairment in glycogen synthase activation appears to result from a defect in the ability of insulin to phosphorylate IRS-1, causing a reduced association of the p85 subunit of PI-3 kinase with IRS-1 and decreased activation of the enzyme PI-3 kinase.

Transcript of our Exclusive Interview: Stanley Schwartz talks with Diabetes in Control Publisher Steve Free during the AACE 2018 convention in Boston about the changing classifications of diabetes, why we need to move beyond thinking in terms of type 1 and type 2, and the need for precision medicine in treating patients with all types of diabetes.

In this Exclusive Interview, Stanley Schwartz talks with Diabetes in Control Publisher Steve Free during the AACE 2018 convention in Boston about the changing classifications of diabetes and the need for precision medicine in treating patients with all types of diabetes.

In part 1 of this Exclusive Interview, Stanley Schwartz talks with Diabetes in Control Publisher Steve Freed during the AACE 2018 convention in Boston about the classification of diabetes and the learnings that have happened since first creating the various diabetes designators.

In part 2 of this Exclusive Interview, Stanley Schwartz talks with Diabetes in Control Publisher Steve Freed during the AACE 2018 convention in Boston about the philosophy behind using multiple drugs to more aggressively treat diabetes earlier in the life of the disease.

In part 3 of this Exclusive Interview, Stanley Schwartz talks with Diabetes in Control Publisher Steve Freed during the AACE 2018 convention in Boston about the effectiveness of multi-drug treatment and the time needed to help a patient to achieve their diabetes management goal.

In part 4 of this Exclusive Interview, Stanley Schwartz talks with Diabetes in Control Publisher Steve Freed during the AACE 2018 convention in Boston about precision medicine, which is identifying beta markers in patients in order to determine the best medications to use.

In part 5, the conclusion of this Exclusive Interview, Stanley Schwartz talks with Diabetes in Control Publisher Steve Freed during the AACE 2018 convention in Boston about the studies that could make a more accurate and effective set of diabetes guidelines and process of care.

New study finds late onset diabetes early sign of pancreatic cancer; African Americans with type 2 diabetes mellitus (T2DM) at a higher risk of developing pancreatic cancer relative to other ethnic groups.

It is time to wake up and smell the coffee (roses) -- Study finds; by providing free A1c tests at all check-ups we could find most of those with prediabetes.