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Rhoda H. Cobin, MD, MACE is Clinical Professor of Medicine at the Ichan School of Medicine at Mount Sinai NYC. She is a founding board member of AACE, served as its president and the president of the American College of Endocrinology. Dr. Cobin's academic interests include reproductive endocrinology, thyroid disease and thyroid cancer, and diabetes. She was one of the chairs for the production of AACe's Disease State Clincial Review : Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome. She and AACE have particularly been concerned for over a decade with increasing awareness of the significant cardiometabolic consequences of PCOS.

In this week's Homerun Slides,  the accuracy of CGMs and the benefit for insulin-using patients.

Gene–gene and gene–environment interactions: Gene–gene interactions, or epistasis, have been suggested as a possible explanation for difficulties in replicating genetic association in complex diseases. The standard statistical methods used in association studies are usually limited to analysis of single marker effects and thereby do not account for interactions between markers. Previous attempts to study epistasis in complex diseases have focused on interactions between candidate regions. However, the recent abundance of GWAS data has made a comprehensive search across the genome more feasible.

In this Exclusive Interview transcript, Rhoda Cobin talks with Diabetes in Control Medical Editor Joy Pape during the AACE 2018 convention in Boston about the association between diabetes and PCOS, the genetic component of PCOS, and the syndrome's long-term health implications.

In this Exclusive Interview, Rhoda Cobin talks with Diabetes in Control Medical Editor Joy Pape during the AACE 2018 convention in Boston about PCOS and diabetes, the genetic component of PCOS, and the syndrome's long-term health implications.

In part 1 of this Exclusive Interview, Rhoda Cobin talks with Diabetes in Control Medical Editor Joy Pape about why the medical community of varying expertise should be concerned about PCOS.

In part 2 of this Exclusive Interview, Rhoda Cobin talks with Diabetes in Control Medical Editor Joy Pape about the impact of obesity on PCOS.

In part 3 of this Exclusive Interview, Rhoda Cobin talks with Diabetes in Control Medical Editor Joy Pape about looking at the genetics of PCOS and when PCOS can actually begin.

In part 4 of this Exclusive Interview, Rhoda Cobin talks with Diabetes in Control Medical Editor Joy Pape about the manifestation of PCOS in women, especially in those with higher levels of testosterone.

In part 5 of this Exclusive Interview, Rhoda Cobin talks with Diabetes in Control Medical Editor Joy Pape about the varying risks and increased mortality in women who have co-morbidities related to PCOS.