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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #84: Measuring Insulin Action In Vivo

The glucose clamp: Rather than using exogenous agents that suppress beta-cell insulin secretion, the glucose clamp uses external feedback control to “open the loop” between insulin secretion and sensitivity. The glucose clamp is a powerful and widely used method to attain a quantitative measure of insulin sensitivity, and has been applied in many hundreds of experimental studies.

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