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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #89: Lipid and Lipoprotein Metabolism, Hypolipidemic Agents, and Therapeutic Goals Part 1

Any discussion of lipid and lipoprotein metabolism in diabetes mellitus, especially type 2 diabetes mellitus (T2DM), must consider the role of insulin resistance (IR). IR plays a central role in the abnormal lipid and lipoprotein metabolism of T2DM [1] as evidenced by the characteristic set of lipid and lipoprotein abnormalities accompanying IR, even in the absence of frank hyperglycemia or abnormal glucose tolerance. Individuals with IR have low plasma levels of HDL-C and elevations in plasma triglyceride (TG) levels compared with levels seen in individuals who have normal insulin sensitivity. There is also an increase in the proportion of low-density lipoprotein (LDL) particles that are small, dense, and cholesterol ester-poor. I

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Medipin® — to Detect Neuropathy

The pinprick or sharp sensation test is acknowledged and recommended by the ADA as a useful and sensitive method of testing for Loss Of Protective Sensation and predicting serious complications associated with diabetes. Medipin is a unique single use cutaneous pinprick testing device. Its patented precision technology has been designed to enhance patient pinprick sensation response.

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