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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #115: Diabetes and Sleep Apnea Part 5

OSA and beta-cell function: While the impact of OSA in IR has been studied extensively, the impact of OSA on beta-cell function has received little attention, despite being an essential part of the pathogenesis of T2DM and prediabetes. A small number of animal studies showed that intermittent hypoxia increases beta-cell death, and results in beta-cell dysfunction, although the intermittent hypoxia used in this study is far greater than that which occurs in humans with OSA.

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