Thursday , November 23 2017
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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #85: Measuring Insulin Action In Vivo

Insulin action dynamics: Insulin sensitivity from the clamp is expressed in terms of the steady-state value reached after a period of hyperinsulinemia. A dose–response can be constructed and sensitivity can be expressed as the ED50, that is, the concentration for half-maximal stimulation of Rd as a function of dose. Alternatively, sensitivity can be expressed (as it usually is) as the Rd at a specific dose of insulin, which may be low, intermediate, or a maximum dose. It is often assumed that steady-state rate of glucose uptake is reached by 180 min after onset of the insulin infusion. In fact, steady-state glucose uptake is not reached at 3h. Glucose uptake rate at 3h is only 2/3 the “true” steady-state, which is not achieved until 6h. Certainly, shorter periods (e.g. 120 min) are inadequate to reflect steady-state rates of uptake.

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…And Stay Active: A Profile in Living Successfully with Diabetes

I have been writing columns—mostly about physical activity and exercise—for this enewsletter for more than a decade, and I am grateful to DIC for allowing me to educate everyone on topics that I feel so strongly about. This month, I would like to switch gears a bit and share some of my personal story about why physical activity matters to me and how I have lived successfully with type 1 diabetes for almost 50 years to date.

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