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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #89: Lipid and Lipoprotein Metabolism, Hypolipidemic Agents, and Therapeutic Goals Part 1

Any discussion of lipid and lipoprotein metabolism in diabetes mellitus, especially type 2 diabetes mellitus (T2DM), must consider the role of insulin resistance (IR). IR plays a central role in the abnormal lipid and lipoprotein metabolism of T2DM [1] as evidenced by the characteristic set of lipid and lipoprotein abnormalities accompanying IR, even in the absence of frank hyperglycemia or abnormal glucose tolerance. Individuals with IR have low plasma levels of HDL-C and elevations in plasma triglyceride (TG) levels compared with levels seen in individuals who have normal insulin sensitivity. There is also an increase in the proportion of low-density lipoprotein (LDL) particles that are small, dense, and cholesterol ester-poor. I

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Medipin® — to Detect Neuropathy

The pinprick or sharp sensation test is acknowledged and recommended by the ADA as a useful and sensitive method of testing for Loss Of Protective Sensation and predicting serious complications associated with diabetes. Medipin is a unique single use cutaneous pinprick testing device. Its patented precision technology has been designed to enhance patient pinprick sensation response.

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Acanthosis nigricans

Test Your Knowledge

Acanthosis nigricans presents as a brown to black pigmentation usually seen in the neck or armpit areas. In relation to diabetes, this may indicate: A) granuloma annulare B) diabetic dermopathy C) type 1 diabetes D) insulin resistance Follow the link to see the correct answer.

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What’s Your Number?

Because the A1c test is important for more than diagnosing diabetes and prediabetes, it is important that we each know what our A1c is. Do you know what your A1c number is? Follow the link to share your response!

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Current Interview: Linda Siminerio

Dr. Linda Siminerio RN, PhD is a Professor of Medicine at the University of Pittsburgh and Executive Director of the University of Pittsburgh Diabetes Institute. Dr. Siminerio has organized 44 diabetes self-management education programs throughout western Pennsylvania and for the U.S. military at Wilford Hall Medical Center at the Lackland Air Force Base in Texas. Dr. Siminerio’s primary research topics include diabetes education, diabetes translation into community interventions, pediatric diabetes care and education, and the psychosocial and behavioral aspects of diabetes.

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