Saturday , October 21 2017
Home / Resources / Articles / Researchers Identify Genetic Regions Associated with Type 2 Diabetes

Researchers Identify Genetic Regions Associated with Type 2 Diabetes

Analysis of DNA data reveals important information in largest diabetes genetic study to date…. 

Researchers have discovered seven new gene locations associated with type 2 diabetes. Researchers and investigators from Oxford University’s Wellcome Trust Centre for Human Genetics used meta-analyses of genome-wide association studies to look at DNA data from over 47,000 patients and 139,000 control subjects from four different ethnic groups: European, East Asian, South Asian, and Mexican & Mexican-American descent.

As more genetic DNA becomes available, especially from more diverse populations, the more closely genes associated with type 2 diabetes can be mapped. Researchers were able to combine DNA data from tens of thousands of individuals and detect genetic regions where the effects of diabetes susceptibility may be subtle.

Two such genetic regions that the researchers identified are near the genes known as ARL15 and RREB1 which are associated with abnormal levels of insulin and glucose in the body, characteristics of type 2 diabetes.

Dr. Anubha Mahajan of Oxford University stated that these findings, "may lead us to new ways of thinking about diabetes, with the aim ultimately of developing novel therapies to treat and prevent diabetes."

Practice Pearls: 
  • Seven new loci, or gene locations within a chromosome that are associated with type 2 diabetes have been newly discovered
  • Two of the identified genetic regions lie near the genes known as ARL15 and RREB1, genes associated with abnormal levels of insulin and glucose in the body.

http://www.nature.com/ng/journal/vaop/ncurrent/ng.2897/metrics