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Regression from Prediabetes to Normal Glucose Reduces CVD Risk

Jul 25, 2014

But risk for CVD was higher in the prediabetes group than for those who already had diabetes, probably due to increased medication…. 

In participants of the Diabetes Prevention Program with normal glucose regulation (NGR) restored at least once during the program, CVD risk factors were calculated annually for 10 years and compared with those of participants who developed diabetes or stayed diabetic (n = 2775). The mean Framingham 10-year CVD risk scores for NGR, prediabetes, and diabetes groups were 15.5%, 16.2%, and 15.5%, respectively, at baseline. Scores in the prediabetes group decreased to 15.9% by year 10 (P < .01).

The Framingham (2008) score (as an estimate of the global 10-year CVD risk) and individual CVD risk factors were calculated annually for the Diabetes Prevention Program Outcomes Study years 1–10 among those patients who returned to NGR at least once during the Diabetes Prevention Program (DPP) compared with those who remained with prediabetes or those in whom diabetes developed during DPP (N = 2,775).

The Framingham scores by glycemic exposure did not differ among the treatment groups; therefore, pooled estimates were stratified by glycemic status and were adjusted for differences in risk factors at DPP baseline and in the treatment arm. During 10 years of follow-up, the mean Framingham 10-year CVD risk scores were highest in the prediabetes group (16.2%), intermediate in the NGR group (15.5%), and 14.4% in people with diabetes (all pairwise comparisons P < 0.05), but scores decreased over time for those people with prediabetes (18.6% in year 1 vs. 15.9% in year 10, P < 0.01). The lower score in the diabetes group versus other groups, a declining score in the prediabetes group, and favorable changes in each individual risk factor in all groups were explained, in part, by higher or increasing medication use for lipids and blood pressure.

In conclusion, prediabetes represents a high-risk state for CVD. Restoration of NGR and/or medical treatment of CVD risk factors can significantly reduce the estimated CVD risk in people with prediabetes.

Practice Pearls:
  • Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk.
  • Restoration of normal glucose regulation in people with prediabetes significantly decreases the risk of future diabetes

Diabetes Care 2014 Jun 26;[EPub Ahead of Print], L Perreault, M Temprosa, KJ Mather, E Horton, A Kitabchi, M Larkin, MG Montez, D Thayer, TJ Orchard, RF Hamman, RB Goldberg