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Reduction in A1c Relates to Decreases in hs-CRP

Poorly controlled type 2 diabetes patients with self-monitoring of blood glucose protocol have been shown to decrease high-sensitivity C-reactive protein levels…. 

To examine the effect of a structured SMBG protocol associated decrease in A1c on the changes in hs-CRP, Oliver Schnell, from the Helmholtz Center Munich, and colleagues conducted a randomized study on 483 poorly-controlled insulin-naïve patients with type 2 diabetes. Participants were randomized to either an active control (ACG) or structured testing (STG).

The results of the study showed that at 3, 6, 12 months, the reductions in hs-CRP for the STG group were greater than the ACG group. In patients with high cardiovascular risk, the hs-CRP was lower in the STG group than the ACG group. Both groups showed a strong relationship between decreases in hs-CRP and hemoglobin A1c.

The authors state, "Our study is the first to report a relationship between the significant glycemic outcomes of a structured SMBG intervention and changes in hs-CRP, a clinical marker of cardiovascular risk.

Changes in A1C Levels Are Significantly Associated With Changes in Levels of the Cardiovascular Risk Biomarker hs-CRP: Results from SteP Study. Diabetes Care. February 22, 2013, doi:10.2337/dc12-1711