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Question #875

A 34-year-old female presents to your office for a new patient visit. Her medical history is positive for gestational diabetes mellitus (GDM). The Diabetes Prevention Program Research Group found that implementing intensive lifestyle modifications and prescribing metformin resulted in an equivalent risk reduction of developing diabetes by:

Correct

Answer C. 50%

Educational Critique: A past history of GDM is considered a significant risk factor for the development of diabetes, in particular, type 2. The Diabetes Prevention Program (DPP) was a large prospective study that examined the impact of intensive lifestyle interventions or metformin therapy on the development of type 2 diabetes for individuals with impaired glucose tolerance. Participants were assigned either to a placebo, metformin or intensive lifestyle intervention group. R.E. Ratner, et al. (2008) conducted an analysis of the women enrolled in the DPP; parous women, with or without a history of GDM. Women with a history of GDM who received intensive lifestyle interventions or metformin therapy showed a 50% reduction in the incidence of diabetes compared to the placebo group. Women with no history of GDM who received intensive lifestyle interventions or metformin therapy showed 49% (ILS) and 14% (metformin) reductions in the incidence of diabetes compared to the placebo group. The authors concluded that both intensive lifestyle interventions and metformin therapy confer significant benefit in delaying or preventing the development of diabetes in women with a history of GDM or IGT.

Diabetes Care 2016   DiabetesinControl.com

Incorrect