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Question #871

Hypoglycemia is a potential side effect of which of the following classes of drugs:


Answer: All of the above!

Educational Critique: These four drug classes can lead to hypoglycemia. Insulin works by activating the insulin receptors, leading to increased glucose uptake at peripheral tissues and decreased hepatic glucose production. The Sulfonylureas and Meglitinides are both secretagogues. They work by closing the pancreatic beta-cell plasma membrane KATP channels, leading to an increase in insulin secretion. Amylin mimetics act as an angonist and activate the amylin receptors leading to decreased glucagon secretion and slowed gastric emptying (their use requires decreased insulin dose adjustments).

Resource:  Drug Package Inserts