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Question #853

The development of type 2 diabetes is multifactorial. All of the following are thought to play a role in the development EXCEPT:


Answer: 5. Increased skeletal GLUT4 glucose transporters translocation capacity

Educational Critique: Insulin resistance is thought to be multifactorial. While it appears that the insulin receptor may be defective in some individuals with type 2 diabetes, distal post-receptor pathways are thought to play a significant role. One element of this is the decreased capacity for translocation of GLUT4, the muscle/fat cell surface. GLUT4 is contained in intracellular membrane vesicles that move to the cell surface under the presence of insulin. GLUT4 transporters are responsible for facilitating the facultative movement of glucose from outside to inside the cell cytoplasm where the glucose is then phosphorylated. -- J Cell Sci. 2011 Dec 15; 124(24): 4147–4159. doi:  10.1242/jcs.097063