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Protein in Aging Process Linked to Glucose Production

Nov 14, 2014

Researchers have identified a small protein with a big role in lowering plasma glucose and increasing insulin sensitivity. The report indicates that Sestrin 3 – found to operate in multiple biological processes, including resistance to oxidative and genotoxic stresses, protection against aging-related pathologies, and promotion of metabolic homeostasis – plays a critical role in regulating molecular pathways that control the production of glucose and insulin sensitivity in the liver, making it a logical target for drug development for type 2 diabetes and metabolic syndrome, which can produce increased blood pressure, abnormal cholesterol levels and insulin resistance. Sestrin 3 is a member of a small family of proteins that have long been known to suppress oxidative stress and regulate normal cellular activity. Appears online in Diabetes, Nov 2014