Patients in this recent study were randomized to take either metformin 850mg twice daily or placebo, or undergo intensive lifestyle changes using diet and exercise in order to measure subsequent lipoprotein subfraction size, density, and concentration. Magnetic resonance and density gradient ultracentrifugation, was used to measure lipoprotein at baseline and after 1 year.
Intense lifestyle changes decreased very low density lipoprotein and low density lipoprotein, while raising large high density lipoprotein. Metformin modestly decreased LDL, and increased HDL.
The authors concluded that intense lifestyle changes involving weight loss, diet, and exercise in order to decrease weight by 7%, and metformin treatment have favorable effects on lipoprotein subfractions. It was also noted that retarding the progression of diabetes may slow the development of atherosclerosis.
- Intense lifestyle changes decreases LDL and increases HDL after 1 year.
- Metformin decreases LDL and increases HDL.
- Slowing the progression of diabetes may reduce the development of atherosclerosis.
Journal of Clinical Endocrinology and Metabolism, August 2013