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Positive Correlation Between Coffee Consumption and Adiponectin Levels

Diabetics who drink coffee had significantly lower HbA1c and higher adiponectin compared to those who did not…

Researchers from India and Trinidad studied the levels of adiponectin in coffee drinkers for type 2 diabetes (DM2) and non-diabetic patients.

This was a cross-sectional study including 220 non-diabetic subjects, 143 of who consumed coffee and 77 did not. They were matched with 90 diabetic subjects, 48 consumed coffee and 42 did not. Coffee consumption was more than three cups per day for more than 15 years. The primary outcome was to determine the amount of adiponectin in DM2 versus normal subjects. Fasting blood sugar of 5 ml was collected and adiponectin was determined using ELISA. An unpaired t-test was used to analyze FBS, PPBG, HbA1c and adiponectin.

The results showed no significant difference (P<0.05) in FBG and PPBG for diabetic and coffee status. HbA1c and adiponectin levels were significantly different in diabetic and coffee status. Diabetics who drink coffee had significantly lower HbA1c and higher adiponectin compared to those who did not.

This study showed that diabetic patients in the coffee-consumption group had lower fasting blood glucose compared to those who never consumed coffee. There was also a positive relationship between coffee consumption and adiponectin level, which is consistent with previous studies.

Practice Pearls:

  • Not everybody drinks 3 cups of coffee per day for 15 years, but those that have may be at a lower risk of type 2 diabetes.
  • Coffee contains caffeine, which is responsible for the up-regulation of peroxisome proliferation-activated receptor γ expression, resulting in increased adipocyte expression and increased adiponectin secretion.
  • With future studies, we can find other methods to increase adiponectin besides caffeine.

Geetha Bhaktha. “Relationship of Caffeine with Adiponectin and Blood Sugar Levels in Subjects with and without Diabetes.” J Clin Diagn Res. 2015 Jan; 9(1): BC01–BC03.