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Plasma Copeptin a Potential Marker for CVD in Asymptomatic T2DM Patients

Aug 23, 2014

Copeptin concentration also correlated to plasma creatinine and to PAD in T2DM patients…. 

Both arginine vasopressin (AVP) and copeptin have been investigated as biomarkers for cardiovascular disease (CVD) in type 2 diabetes (T2DM). AVP plays an important role in cardiovascular homeostatis; however, due to the short half-life, it is not very stable in plasma at room temperature. Meanwhile, copeptin has the same precursor as AVP but with a longer half-life: it is normally preferred over AVP for better measurements in plasma samples. In previous studies, copeptin has been associated with acute myocardial infarction, chronic heart failure, CVD and all-cause mortality in T2DM. Recently, Dr Bar-Shalom and colleagues from Odense University Hospital in Denmark investigated the correlation of copeptin to CVD in asymptomatic T2DM patients.

The study included 302 diabetes patients with no known or suspected CVD in the intervention group and 30 healthy adults in the control group. The copeptin levels were analyzed using a Kryptor device, and CVD was evaluated based on 3 different scores: peripheral arterial disease (PAD), carotid arterial disease (CAD) and summed stress score (SSS). The results of the study indicated that there was no difference in the median plasma copeptin concentration in the T2DM group compared to the control group. In relation to gender, T2DM men had significant higher copeptin concentrations compared to men without T2DM (p=0.038) as well as to T2DM women (p<0.001). According to the authors, "copeptin correlated significantly with age, duration of diabetes, systolic blood pressure, hemoglobin, insulin, C-peptide and creatinine (p<0.001)." Also, copeptin tended to associate significantly with PAD but not with CAD or SSS.

Overall, the results of this study were comparable to previous studies when they showed that copeptin concentration was correlated to plasma creatinine and to PAD in T2DM patients.

Practice Pearls:
  • Plasma copeptin could be a marker for PAD in asymptomatic T2DM patients.
  • Copeptin concentrations tend to be higher in T2DM men than in T2DM women.
  • Copeptin concentrations seem to correlate with creatinine concentrations.

Bar-Shalom D, Poulsen MK, Rasmussen LM, et al. Plasma copeptin as marker of cardiovascular disease in asymtomatic type 2 diabetes patients. Diab Vasc Dis Res 2014; pii:1479164114544464.