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Patients with Diabetes Exhibit “Higher Risk Profile” after PCI

Oct 3, 2013

Diabetic patients have a higher mortality rate after undergoing a PCI after an acute myocardial infarction…. 

In a study conducted by Sanidas et al, the outcome in patients with diabetes who underwent a PCI after having a STEMI was examined.

The observational study, which extracted patient data from the INFUS-AMI trial, consisted of 451 individuals, 51 of whom had diabetes. All of these patients were diagnosed with an anterior STEMI due to an obstructed left anterior descending artery (LAD) and were treated with a "bivalirudin-supported primary PCI." After 30 days following the procedure, patients had follow-up visits to evaluate their "clinical, angiographic, and cardiac magnetic resonance imaging (cMRI) results."

After the follow-up period, it was found that the patients with diabetes had significantly more complications and were faced with a more severe LAD condition. Although the PCI was effective in restoring blood flow in patients with and without diabetes, patients with diabetes were associated with more cardiovascular problems after a 1-year follow-up. Furthermore, patients with diabetes experienced a higher rate of stent thrombosis within 30 days after the PCI was performed.

In conclusion, while a PCI after a STEMI was shown to be effective among diabetic patients, these patients were still at a higher risk for other complications and for a rebound myocardial infarction. In the long run, diabetic patients had higher mortality rates, experienced stent thrombosis more often and revascularization, than patients without diabetes.

Sanidas EA et al. Outcomes in diabetic patients undergoing primary percutaneous coronary intervention for acute anterior myocardial infarction: Results from the INFUSE-AMI study. Catherization Cardiovascular Interventions. EASD 2013. Abstract. doi: 10.1002/ccd.25203