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Omega-3 Fatty Acids and Statin Combination Therapy

Jul 19, 2013

For some type 2 diabetic patients, statin medications alone might not be enough…. 

This study evaluated the effects and safety of omega 3 fatty acids combined with a statin in type 2 diabetic patients with dyslipidemia. Fifty one patients were assessed in a randomized, open label study in Korea for 8 weeks of treatments. Participants were randomly chosen to receive either a combination of statin drug and omega-3 fatty acid 2 g, 4 g, or just statin alone. Mean low density lipoprotein (LDL) particle size, triglyceride (TG) and A1c level were measured at 4 weeks and 8 weeks follow ups.

The results showed no significant change in A1c in all three groups with mild complaints of diarrhea, flushing, and dyspepsia. In all groups, neither high density lipoprotein cholesterol (HDL-C) nor low density lipoprotein cholesterol (LDL-C) level showed any improvement. However, total cholesterol and triglyceride level was significantly reduced in patients with 4g of omega 3. There was no marked difference between statin alone and combination of 2g of omega 3 fatty acid group in 8 weeks treatments.

Omega-3 fatty acids are well known to reduce the TG level. However, bigger and longer trials are required to further establish the benefit of omega-3 fatty acids with statin combination therapy in diabetic patients with dyslipidemia.

Lee M, Park JK, Hong JW, et al, Beneficial Effects of Omega-3 Fatty Acids on Low Density Lipoprotein Particle Size in Patients with Type 2 Diabetes Already under Statin Therapy. Diabetes Metab J 2013;37:207-211