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Old vs. New: Which T2D Agents Have the Best Renal Outcomes?

Oct 24, 2020

Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Destiny Reed, PharmD. Candidate, Florida A&M College of Pharmacy and Pharmaceutical Sciences

How do DPP-4 inhibitors and sulfonylureas compare to SGLT2is and GLP-1 agonists regarding renal outcomes?

T2D is associated with micro- and macrovascular complications that significantly increase the burden of this disease. Diabetic nephropathy is one such complication associated with increased mortality and reduced quality of life in diabetes patients. Trials such as the CREDENCE and EMPA-REG OUTCOMES trials have shown the benefit of SGLT2is in preventing kidney disease progression and reducing outcomes. There is a lack of evidence that confirms the effectiveness of antihyperglycemic agents in the real world setting or compares current agents' effectiveness in reducing renal effects.

A new study aimed to provide real-world evidence to compare older add-on antihyperglycemic agents' effectiveness versus newer agents in reducing renal outcomes....

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