A marker called AIM (apoptosis inhibitor of macrophage) is an important factor in the autoimmune process. The inhibition of AIM may stop the body from producing antibodies which attack the self….
The researchers observed a rise in immunoglobulin M (IgM) in the mice that were fed a high-fat diet. Fatty acids from the high fat diet stimulated particular immune cells that led to a rise in IgM. In addition, IgM binds to AIM in the bloodstream and prolonged exposure of this complex lead to the production of auto-antibodies. The mice that lacked the AIM in the blood were protected from auto-antibodies.
The researchers concluded that the interception of AIM could affect chronic inflammation (innate immunity) and auto-antibody production (humoral immunity). These are two immune responses associated with obesity.
In the future, the researchers think that therapy could incorporate AIM inhibition to prevent autoimmune obesity-related metabolic disorders.
Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.03.006