DISASTERS AVERTED — Near Miss Case Studies
EXCLUSIVE INTERVIEW — Candid Video Interviews with Top Practitioners
Michael Irwig on Treating Low Testosterone
HOMERUN SLIDES — Great Clinical Presentation Highlights
CGM Review of Clinical Outcomes Studies Part 1
CLINICAL GEMS — The Best from Diabetes Texts
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #149: Glucose Toxicity Part 5
MOST POPULAR ARTICLES OF THE MONTH
#1 WHO Guidelines Recommend Treatment Intensifications in Type 2 Diabetes
#2 Delaying the Progression of Type 1 Diabetes
#3 Nuts, Nuts, and More Nuts Lower A1c and Cardiovascular Disease
Editor's Note
A few years back, I was working with an endocrinologist in St. Petersburg, managing his diabetes patients. We would get a lot of type 2 patients who had been started on basal insulin and then referred to us when their condition required the addition of mealtime insulin. Most of these male patients were in their late 50’s / early 60’s and many of them had lost muscle mass and had added on significant abdominal fat. In addition, many of them had expressed loss of libido; however, when they had spoken to their primary care physicians, it was usually explained away as a symptom of old age.
Dave Joffe
Editor-in-chief
DISASTERS AVERTED — Near Miss Case Studies
When a patient is prescribed a timed-release medication such as Glucotrol XL or Glucophage XR, clinicians need to ensure that the patients understand that they should not crush, chew, or cut these pills. The medications must be swallowed whole.
EXCLUSIVE INTERVIEW — Candid Video Interviews with Top Practitioners
Michael S. Irwig, MD, F.A.C.E., is board-certified in Endocrinology & Metabolism and is an associate professor of Medicine at The George Washington University School of Medicine & Health Sciences. He also is an adjunct associate professor of Medicine at Georgetown University School of Medicine.
HOMERUN SLIDES — Great Clinical Presentation Highlights
In this week’s Homerun Slides, we begin a new series showing the value of continuous glucose monitoring.
CLINICAL GEMS — The Best from Diabetes Texts
The effects are consistent with a role for O-GlcNAc in damping acute hormone- and phosphorylation-mediated signals in situations of chronic nutrient excess. Although discovered in the context of diabetes, the aforementioned changes mediated by the HBP can also be viewed as adaptive responses to excess nutrient flux: muscle cells protect themselves from excess glucose fluxes and the excess nutrients are eventually stored as fat. Indeed, if insulin signaling were not dampened and glycogen synthesis were effectively engaged even with overeating, a pound of ingested carbohydrate would result in approximately four pounds of hydrated glycogen in muscle, and it is easy to visualize diets rich in sodas and donuts resulting in the development of glycogen storage diseases.
MOST POPULAR ARTICLES OF THE MONTH
Medications suggested for second- and third-line treatments for diabetes management following treatment failure with metformin and sulfonylureas.
Exercise can lengthen remission after being diagnosed with type 1 diabetes.
New study shows that nut intake may improve glycemic control and reduce risk of cardiovascular disease in people who have type 2 diabetes.