October 9, 2018 : DCMS #418

DISASTERS AVERTED — Near Miss Case Studies

Talk About Aspirin With Your Patients

EXCLUSIVE INTERVIEW — Candid Video Interviews with Top Practitioners

Lisa Letourneau on Monogenic Diabetes

HOMERUN SLIDES — Great Clinical Presentation Highlights

Endocrinology Jeopardy: Pituitary for $100!

CLINICAL GEMS — The Best from Diabetes Texts

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #146: Glucose Toxicity Part 2

MOST POPULAR ARTICLES OF THE MONTH

#1 A Major Diabetes Complication That We Fail to Address
#2 Nuts, Nuts, and More Nuts Lower A1c and Cardiovascular Disease
#3 When and When Not to Use An SGLT-2

This week I got a new update from 23 and Me. They had some new data on the effects of gene mutations on major disease and when I looked up diabetes they let me know…based on a few large studies, it is estimated that 30-80% of the risk of developing type 2 diabetes may be explained by genetic factors.

This week we have a private interview with Lisa Letourneau, MPH, RD, LDN at the University of Chicago, Kovler Diabetes Center, as she discusses the latest research on diabetes and genetic therapy.

Dave Joffe

Editor-in-chief

Male, 69 years of age, coronary artery disease,  two cardiac stents, hypertension, hyperlipidemia, prediabetes, bladder cancer.  His sister is 64 years of age, coronary artery disease, prediabetes, PCOS, elevated cardiac calcium score of >1000, no hyperlipidemia. HO early heart disease, stroke, and early death in family.

There have been recent reports in the media speaking of the ASPREE Trial, which reported that taking aspirin daily is not effective for all people, and in some it may be more detrimental due to bleeding risks.

Lisa Letourneau, MPH, RD, LDN, is a diabetes researcher, dietitian, and public health professional. As Diabetes and Genetics Clinical Research Manager at the University of Chicago, her work focuses on managing multiple studies related to atypical diabetes, including the largest monogenic diabetes registry in the United States.

In this week’s Homerun Slides, we bring you the first question in little game to test your endocrinology knowledge, from a recent presentation by Dr. Claude Lardinois. For (a fictional) $100, this was discovered as part of an evaluation for headaches.

Chronic hyperglycemia as a cause of insulin Resistance: Insulin resistance in patients with type 1 diabetes—a consequence of glucose toxicity? Insulin resistance both precedes and predicts type 2 diabetes and therefore is not merely due to hyperglycemia. In the case of type 1 diabetes, it is clear that insulin resistance is an acquired and reversible phenomenon since insulin sensitivity is completely normalized during remission of the disease.

Nonadherence to diabetes medications 2nd leading cause of hospitalizations

New study shows that nut intake may improve glycemic control and reduce risk of cardiovascular disease in people who have type 2 diabetes.

After reviewing evidence, a tool to evaluate benefit and risk has been developed for the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors.