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Newly Diagnosed Type 2’s Show Signs of Macrovascular Disease

Study concludes that newly diagnosed never treated patients with type 2 diabetes without any cardiovascular risk factors show early manifestations of macrovascular disease.

A group of investigators led by Dr Sayeeda Rahman of the Universiti Sains Malaysia, Kelantan, Malaysia, compared two groups of 30 patients each with type 2 diabetes or impaired glucose tolerance (IGT), to 30 age- and sex-matched non-glycaemic subjects. Patients were newly diagnosed, never treated, normotensive, non-obese, non-hyperlipidaemic and non-smoking.

The researchers found that pulse wave velocity (PWV), a haemodynamic variable, was significantly higher in patients with type 2 diabetes (10.4 ± 2.6 m/s vs 8.7 ± 1.3 m/s; p = 0.035) and trending towards significance in patients with IGT (9.5 ± 1.6 m/s vs 8.7 ± 1.3 m/s; p = 0.078) compared with normoglycaemic control subjects. They also found that augmentation index (AI) appeared to be higher, but not significantly so, both in patients with type 2 diabetes (134.5 ± 17.3% vs 129.2 ± 11.2%; p = 0.055) and IGT (132 ± 16.1% vs 129.2 ± 11.2%; p = 0.059) compared with normoglycaemic subjects.

The researchers conclude that newly diagnosed never treated patients with type 2 diabetes without any cardiovascular risk factors show early manifestations of macrovascular disease, as shown by increased arterial stiffness.

Diabet Res Clin Pract. 2008;80:253-8.

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FACT:
BP-Related Disease Should Be a Global Priority: Eighty percent of deaths connected to high blood pressure occur in the developing world, and much of the burden is borne by those with prehypertension, new research shows. In addition, current programs do not target many of the affected countries, say the study authors. Such a travesty cannot be allowed to continue, ay accompanying editorialists.    (Lancet. May 3, 2008;371:1480-1482, 1513-1518.)