Wednesday , October 18 2017
Home / Resources / Articles / New Treatment For Type 1 Diabetes

New Treatment For Type 1 Diabetes

When mice are given IL-35, type 1 diabetes is either reversed or completely cured as blood glucose returned to normal…

Type 1 diabetes is considered an autoimmune disease in which the immune system attacks insulin-producing beta pancreatic cells. To better understand how to treat type 1 diabetes, Swedish researchers injected mice with a naturally occurring chemical compound known as streptozotocin, which is toxic to beta cells, causing the mice to develop symptoms of type 1 diabetes such as elevated blood glucose levels.

The researchers then examined the role of immune regulating T-cells in the mice and found that the T-cells in the type 1 diabetic mouse models produced proteins to promote inflammatory responses that eventually destroy beta cells instead of promoting the production of anti-inflammatory proteins such as interleukin-35 (IL-35).
IL-35 levels were also compared in human patients with type 1 diabetes and patients without the condition, and it was found that IL-35 was lower in type 1 diabetes patients. The researchers were also able to discover the mechanism in the mice that caused T-cells to change and produce the destructive proteins.

After injecting the mice with streptozotocin, the researchers then also injected the mice with IL-35 and noticed that the IL-35 prevented the mice from developing full blown type 1 diabetes as well as regulated blood glucose levels in mice who had been diabetic for two days.

The findings of this study show that when mice are given IL-35, type 1 diabetes is either reversed or completely cured as blood glucose returned to normal. Human trials are expected to be conducted within the near future.

Practice Pearls:

  • T-cells in type 1 diabetic mouse models produced proteins to promote inflammatory responses that eventually destroys beta cells instead of promoting the production of anti-inflammatory proteins such as interleukin-35 (IL-35).
  • IL-35 levels were also compared in human patients with type 1 diabetes and patients without the condition, and it was found that IL-35 was lower in type 1 diabetes patients.
  • The findings of this study shows that when mice are given IL-35, type 1 diabetes is either reversed or completely cured as blood glucose returned to normal.

Singh K, Kadesj√∂ E, Lindroos J, et al. “Interleukin-35 administration counteracts established murine type 1 diabetes – possible involvement of regulatory T cells.” Science Reports. 2015; 5:12633.