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New Product Omacor

Omacor (Omega-3 Acid Ethyl Esters) Reduces Triglycerides by 45% Evidence SUGGESTS that Omacor 1 g/day can prevent recurrent heart attacks…but this still needs to be proven.

Omacor, the first PRESCRIPTION omega-3 fatty acids will be available by prescription. It contains the omega-3s EPA and DHA derived from fish oil. Omacor is only approved to lower very high triglycerides… 500 mg/dL or more. It can lower very high TGs as much as 45%. New Product

Omacor (Omega-3 Acid Ethyl Esters) Reduces Triglycerides by 45%
Evidence SUGGESTS that Omacor 1 g/day can prevent recurrent heart attacks…but this still needs to be proven.

Omacor, the first PRESCRIPTION omega-3 fatty acids will be available by prescription. It contains the omega-3s EPA and DHA derived from fish oil. Omacor is only approved to lower very high triglycerides… 500 mg/dL or more. It can lower very high TGs as much as 45%. MORE INFORMATION

Omacor comes in 1 g capsules. Patients will take 4 g/day to lower triglycerides. This dose costs about $140/month. Omacor costs more than most fish oil SUPPLEMENTS…but it’s also more concentrated. Each capsule contains 465 mg of EPA and 375 mg of DHA. That’s about three times the amount in most supplements.

Don’t expect Omacor to take the place of fibrates or niacin. Fibrates are more effective for lowering triglycerides. Niacin works at least as well as Omacor on triglycerides and also improves HDL and LDL.

Omacor’s mechanism of action is not completely understood. Potential mechanisms of action include inhibition of acyl CoA:1,2-diacylglycerol acyltransferase and increased peroxisomal beta-oxidation in the liver. Omacor interferes with the liver’s ability to synthesize triglycerides as EPA and DHA are alternative substrates for enzymes responsible for TG synthesis. EPA and DHA also inhibit esterificaton of other fatty acids. Omacor is indicated as an adjunct to diet to decrease triglyceride levels of adults with very high triglycerides (>500 mg/dL).

The daily dose of Omacor is 4 g per day, which can be taken as a single dose of four capsules daily or as two capsules twice daily with meals. Omacor is well tolerated with total adverse events leading to discontinuation of treatment in 3.5% of patients versus 2.6% of placebo-treated patients. The most commonly reported adverse effects during clinical trials included dyspepsia, burping, and taste changes (primarily fishy taste).

The effect of Omacor and concomitant anticoagulant usage has not been studied. However, some studies have shown prolonged bleeding time with concomitant use of omega-3 fatty acids and anticoagulants. Patients on concomitant therapy of Omacor and an anticoagulant should be monitored periodically. Omacor should be used with caution in patients with known sensitivity or allergy to fish.
Product information: http://www.solvay-omacor.com/