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New Enzyme Inhibitor May Prevent Onset of Type 2 Diabetes

The new drug apparently works by stabilizing metabolites of an omega-3 fatty acid called DHA…

Researchers Bruce Hammock at the University of California, Davis, and Joan Claria at the University of Barcelona found that an enzyme called soluble epoxide hydrolase, or sEH, inhibitor both prevented the onset of diabetes and reversed its effects in obese mice.

The potent enzyme inhibitor discovered by Hammock’s laboratory dramatically reduces inflammation, inflammatory pain and neuropathic pain.

The previous studies show the drug that they were working on will reduce the symptoms of diabetes in mice by itself. If the mice have a genetically increased level of omega-3 fatty acids the drug offers prevention or even a cure.

The new drug apparently works by stabilizing metabolites of an omega-3 fatty acid called DHA. These metabolites are thought to contribute to the beneficial effects of a diet high in omega-3 fatty acids.

Previous UC Davis research has shown that the enzyme reduces or reverses such diabetes-linked medical issues as renal failure, hypertension, diabetic pain, hardening of the arteries and heart failure.

Claria described the administration of the sEH inhibitor as “a promising strategy to prevent obesity-related co-morbidities.”

Practice Pearls:

  • An enzyme called soluble epoxide hydrolase prevented the onset of diabetes and reversed its effects in obese mice.
  • Studies show the drug that they were working on will reduce the symptoms of diabetes in mice by itself. If the mice have a genetically increased level of omega-3 fatty acids the drug offers prevention or cure.
  • The new drug apparently works by stabilizing metabolites of an omega-3 fatty acid called DHA. These metabolites are thought to contribute to the beneficial effects of a diet high in omega-3 fatty acids.

Cristina López-Vicario, Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides
PNAS, Jan 2015, doi: 10.1073/pnas.1422590112