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MRI Technique Can Help Detect Pancreatic Inflammation

Ferumoxytol-MRI provided clear images of ongoing pancreatic inflammation in patients with new-onset type 1 diabetes. Using the technique may help identify patients showing diabetes progression and stratify subgroups that may respond to various treatments. The researchers investigated the possibility of using MRI and ferumoxytol, a coated iron nanoparticle used as an iron replacement therapy, to image inflammation in the pancreas. Ferumoxytol leaks from blood vessels in areas of inflammation and is taken up by immune cells called macrophages, which accumulate at sites of inflammation. — PNAS, February 17, 2015, Vol. 112:7, pp. 2139-2144