Home / Resources / Articles / Mortality in Heart Failure Associated with Hyperglycemia

Mortality in Heart Failure Associated with Hyperglycemia

Feb 22, 2013
 

Elevated blood glucose level was an independent predictor of 30-day mortality in acute heart failure….

In a large multinational cohort, researchers examined the ability of blood glucose concentration to predict all cause mortality by 30 days. Out of the 6,212 patients involved in this study, 2,484 (41%) of the patients had a past diagnosis of diabetes. Blood glucose concentration was collected from the patients on admission. The median blood glucose for all patients on admission was 135mg/dl.

A fully adjusted model indicated that an elevated blood glucose level was an independent predictor of 30-day mortality in acute heart failure (OR=2.19; 95% CI, 1.69-2.83). Elevated blood glucose concentrations remained associated with increased risk for mortality across all subgroups of patients, the researchers said, including those with preserved (HR=5.41; 95% CI, 2.44-12) and impaired (HR=2.37; 95% CI, 1.57-3.59) systolic function. Analyses also showed that the addition of blood glucose level to clinical parameters resulted in a net reclassification improvement of 4.4% (95% CI, 0.99-7.78).

Overall, 618 patients (10%) died during the 30-day study. The researchers found an average blood glucose concentration of 160mg/dl among patients with acute heart failure who died when compared to a blood glucose concentration of 133mg/dl with those who survived 30 days after presentation.

“Because blood glucose is easily modifiable, it may represent a valid target for therapeutic intervention.”

Mebazaa A. J Am Coll Cardiol. 2013;doi:10.1016/j.jacc.2012.11.054. 

Submitted by Sara DAkroub, PharmD Candidate