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Low Pregnancy Vitamin D Levels Up Child’s Diabetes Risk

Lower maternal serum concentrations of 25-hydroxy-vitamin D (25-OH D) during pregnancy are associated with an increased risk of offspring developing type 1 diabetes during childhood, according to a study. Using radioimmunoassay, 25-OH D levels were measured on late pregnancy samples from 109 women whose offspring developed type 1 diabetes before 15 years of age (cases) and from 219 control women. The investigators found that on categorizing maternal 25-OH D levels into quartiles, there was a trend toward higher type 1 diabetes risk with lower vitamin D levels during pregnancy. Children of women with the lowest levels of 25-OH D had a more than two-fold higher odds of developing type 1 diabetes than children of women with levels above the upper quartile. The authors wrote, “The results indicate an association between lower maternal serum concentrations of 25-OH D during pregnancy and increased risk of type 1 diabetes development in childhood.” Diabetes Jan 2012