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Link between Free Fatty Acids and Acute MI, Type 2 Diabetes

Nov 21, 2014
 

Free fatty acids may play an important role in the development of diabetes and cardiovascular diseases…

Diabetes increases the risk of cardiovascular disease and stroke. About 50% of people with diabetes die of cardiovascular disease. Hyperglycemia causes an increase in free fatty acids (FFA), which is derived from lipolysis. An accumulation of FFAs can lead to insulin resistance, vascular dysfunction and myocardial dysfunction. This study investigated the possible association between free fatty acids with myocardial infarction and type 2 diabetes.

 

A total of 242 participants over the age of 60 were selected — 143 healthy participants as the control group; 52 participants with type 2 diabetes; and 47 with acute myocardial infarction. The free fatty acids were measured with high-pressure liquid chromatography (HPLC) within one hour after rehydration. Blood urea nitrogen (BUN), uric acid, glycemic, lipid and blood routine parameters were measured as well.

The results were that triglycerides and glucose levels were significantly higher in participants with type 2 diabetes (TG 2.02 +/-0.22 mmol/L, glucose 7.75 +/-2.93) and acute myocardial infarcation (TG 1.63 +/- 0.88 mmol/L, glucose 5.78 +/- 1.32) compared to healthy participants in the control group (TG 1.12 +/-0.33 mmol/L, glucose 4.90 +/- 0.49 mmol/L). The HDL levels were lower in participants with type 2 diabetes (0.98 +/ 0.18 mmol/L) and acute MI (1.01 +/- 0.22 mmol/L) versus healthy participants (1.30 +/- 0.22). There were lower FFA levels in the acute MI group (2.64) compared to those with type 2 diabetes (2.72) and the control group (2.72).

This study found serum free fatty acid levels were lower in the acute myocardial infarction group compared to those with type 2 diabetes and the control group. The HDL levels were lower in both the acute myocardial infarction and type 2 diabetes groups; the HDL was associated with the free fatty acids in type 2 diabetes.

Practice Pearls:

  • Serum free fatty acid levels were associated with the HDL levels in people with type 2 diabetes.
  • Serum free fatty acid levels were associated with AST in people with acute MI.
  • Free fatty acid levels were lower in people with acute MI.

Lv ZH, Ma P, Luo W, et al. “Association between serum free fatty acid levels and possible related factors in patients with type 2 diabetes mellitus and acute myocardial infarction”. BMC Cardiovascular Disorders. 2014;14(1):159. “http://www.biomedcentral.com/1471-2261/14/159”