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Lifestyle Intervention and Cardiometabolic Risk Factors: POWER-UP Trial

Three different types of weight loss interventions were examined for their effects on blood pressure, lipids, glucose, insulin resistance, and inflammation in obese participants….

The study included 390 obese participants who were randomly assigned to one of the three weight loss intervention programs for 24 months. The first group was Usual Care, which participants visited primary care provider quarterly for education about weight management. The second group was Brief Lifestyle Counseling, which participants had quarterly primary care provider visits and monthly behavioral counseling provided by a trained auxiliary health-care provider. The third group was Enhanced Brief Lifestyle Counseling which was the previous intervention plus weight loss medications or meal replacement.  The primary outcome for this study was the differences in cardiometabolic risk factors among the three different interventions.
 
The results showed a significant reduction in weight loss between Enhanced Brief Lifestyle Counseling group compared to Usual Car group (4.6 kg vs. 1.7 kg). The Enhanced Brief Lifestyle Counseling group also showed a greater improvement in insulin resistance, high density lipoprotein cholesterol (HDL) and triglyceride levels compared to the other weight loss interventions.
 
Based on the findings, the study showed that the bigger weight loss was related with greater improvement in HDL, triglycerides, insulin resistance, and inflammations across the three groups. However, there was no significant improvement in blood pressures, total cholesterol, and low density lipoprotein cholesterol (LDL) level among three groups.
 
Based on the findings of this study, Enhanced Brief Lifestyle Counseling is suggested as a beneficial option for primary care providers to offer to any obese patients who wants to lose weight and reduce some cardiometabolic risk factors.
 
Vetter ML, Wadden TA, Chittams J, et al. Effect of lifestyle intervention on cardiometabolic risk factors: results of the POWER-UP trial. Int J Obes (Lond). 2013 Aug;37 Suppl 1:S19-24. doi: 10.1038/ijo.2013.92.