Pyruvate cycling pathway is a term I have not heard in many years. When I was in pharmacy school, I remember our Medicinal Chemistry professor posting a slide on the overhead, and telling us if we learned this by the end of the semester we would pass the class. Although I don’t remember the pathway, I do remember the term. Now we fast forward 30 years and we see that there are multiple cycling pathways, and many of them have some effect on glucose metabolism, and more importantly, on Pancreatic Beta cells. This week, our excerpt from the clinical text explains how all this functions together.