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Jamie Uribarri Part 6, Medication That Helps Lower AGEs

Mar 9, 2018

In part 6 of this Exclusive Interview, Jamie Uribarri talks with Diabetes in Control Publisher Steve Freed during the ADA 2017 Scientific Sessions in San Diego, CA about whether there is any medication that helps lower AGEs.

Jamie Uribarri, MD, is a physician and clinical investigator at The Icahn School of Medicine at Mount Sinai in New York.

Transcript of this video segment:

Freed: So are there any medications?  Because we have medications to reduce inflammation. I know statins can reduce inflammation. If we can’t measure it, we really don’t know if the medication is going to reduce that. So how do you manage that?

Uribarri: No, we can only extrapolate from studies. For example, metformin, a commonly used drug now for the treatment of diabetes has been shown independently that it reduces the levels of AGEs. So that is based on more experimental studies. So based on that, I am assuming that every time a patient is taking metformin, other factors are being caused independent of the degree of glucose reduction that helps to reduce AGEs, and therefore, inflammation and oxidative distress. But there are no trials where metformin vs. placebo had been done with measurement of all these factors.

Freed: What are some of the other things? It increases your risk for cardiovascular disease because of the inflammation, it increases your risk for kidney disease. What are some of the other things that it increases your risk for?

Uribarri: Well, hypertension is a very, very important factor and that is something that we are always paying attention to. Every time that a patient comes to me with kidney disease related to diabetes, I said, “Please realize that we do not have a specific drug to cure this, we can only approach the problem.” The main two factors for you to do to at least slow down the worsening of disease are tight control of blood sugar and tight control of blood pressure. So paying attention to blood pressure is very, very important.

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