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Item
#9
Coenzyme Q10
Improves Endothelial Dysfunction in Type 2 Diabetes
CoQ10
supplementation improves endothelial function in dyslipidemic
patients with Type 2 diabetes.
The study
assessed whether dietary supplementation with coenzyme Q10
improves endothelial function of the brachial artery in patients
with Type 2 (non-insulin-dependent) diabetes mellitus and
dyslipidemia.
A total
of 40 patients with Type 2 diabetes and dyslipidemia were
randomized to receive 200 mg of coenzyme Q10 or placebo
orally for 12 weeks. Endothelium-dependent and independent
function of the brachial artery was measured as flow-mediated
dilatation and glyceryl-trinitrate-mediated dilatation,
respectively. A computerized system was used to quantitate vessel
diameter changes before and after intervention. Arterial function
was compared with 18 non-diabetic subjects. Oxidative stress and
plasma antioxidant status was assessed.
The
results showed that diabetic patients had impaired flow-mediated
dilation, but preserved glyceryl-trinitrate-mediated dilation, of
the brachial artery compared with non-diabetic subjects.
Flow-mediated dilation of the brachial artery increased by 1.6 %
with coenzyme Q10 and decreased by -0.4 % with placebo
(p = 0.005); there were no group differences in the changes
in pre-stimulatory arterial diameter, post-ischemic hyperemia or
glyceryl-trinitrate-mediated dilation response.
Coenzyme
Q10 treatment resulted in a threefold increase in
plasma coenzyme Q10 (p < 0.001) but did not
alter plasma F2-isoprostanes, oxygen radical absorbance
capacity, lipid concentrations, glycemic control or blood
pressure.
In
conclusion, Coenzyme Q10 supplementation improves
endothelial function of conduit arteries of the peripheral
circulation in dyslipidemic patients with Type 2 diabetes. The
mechanism could involve increased endothelial release and/or
activity of nitric oxide due to improvement in vascular oxidative
stress.
Diabetologia (2002) 45: 420-426
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FACT:
Americans eat an average of 149 pounds of sugar per
person each year.
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