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#7
Proinsulin-like Molecules
Predict CHD
Concentrations of proinsulin-like molecules are a better predictor
of CHD than insulin, report UK researchers.
As part of
the Caerphilly study, researchers measured the concentrations of
insulin, proinsulin-like molecules and risk factors in 1181
non-diabetic men (aged 50-64 years). Incident CHD was recorded
during the 10-14 year follow-up.
In
regression models, concentrations of proinsulin-like molecules,
but not insulin, predicted incident CHD. The predictive value of
these molecules was reduced by around one third after adjustment
for standard risk factors, triglycerides and HDL-C, and by about
half after further adjustment for plasminogen activator
inhibitor-1.
Reference: prospective data from the Caerphilly
Study. Diabetologia 2002; 45: 327-36.
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Did You Know:
Transient
ischaemic attacks (Mini-strokes) occur between two and six times
more frequently in people with diabetes.
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