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Item
#14
Type 2 Diabetes and
Hypertriglyceridemic Hyper ApoB
Based on
triglycerides and apoB rather than triglycerides and LDL
cholesterol, more intensive therapy is required.
A group
of researchers led by Dr Sniderman from McGill University in
Montreal, Canada, measured plasma lipoprotein levels to determine
the various dyslipidemic phenotypes in patients with type 2
diabetes. Patients were divided into phenotypes by a conventional
method based on triglyceride levels ³ or <1.5mmol/L and LDL
cholesterol ³ or <4.0mmol/L, and a new method based on
triglycerides ³ or <1.5mmol/L and apoB ³ or <120mg/dL.
The
researchers showed that for the overall cohort, plasma
triglycerides were elevated (2.13±1.6mmol/L), and total
(5.34±1.1mmol/L) and LDL cholesterol (3.28±0.88mmol/L) were
normal. Using the conventional method, 23% of the cohort had
elevated LDL cholesterol levels, but almost 40% had an elevated
apoB level with the new method. Combined hyperlipidemia was found
in 12.8% of patients with the conventional method compared with
almost 35% with the new method. In the latter group, the mean apoB
level was 145mg/dL, which was in the 95th percentile of
the population.
Based on
triglycerides and apoB rather than triglycerides and LDL
cholesterol, over 20% of patients had hypertriglyceridemic
hyperapoB, which, according to the authors, justifies intensive
therapy. Diabetes Care 2002;25:579-82
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FACT:
The
average woman gains 9 pounds between her 30th and 39th
birthdays, average for guys is just 4 lbs
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