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Item
#11
Repaglinide Best at
Mealtimes Three Times a Day, not Twice
More
effective if given with each meal than just morning and evening
meals.
A group of
researchers led by Dr Schmitz from the University Hospital of
Aarhus, Denmark, studied the effect of meal-related dosing with
repaglinide in patients with diabetes. The group compared
3-mealtime dosing with the same total daily dose when divided into
2 doses given with the morning and evening meals. Overall, 19
patients with type 2 diabetes, mean age 58 years, who were naive
to antidiabetic drugs, were included. Twenty-four hour levels of
blood glucose, plasma insulin, and plasma C-peptide were measured
at baseline and 4 weeks after.
The
researchers showed that repaglinide increased postprandial insulin
levels and reduced postprandial glucose levels compared with
baseline in both treatment groups. Fasting blood glucose and HbA1c
levels were also significantly reduced by repaglinide. Repaglinide
was more effective in improving glycemic control, including
postprandial glucose and HbA1c levels, when given at
each main meal compared with the same total daily dose given with
the morning and evening meals. The authors suggest that, in
addition to classic parameters of glycemic control, postprandial
glucose may also be important because of the possible association
between postprandial hyperglycemia and the risk for cardiovascular
disease in diabetes. Diabetes Care 2002;25:342-6
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Did You Know:
There
are programs which can help your patients receive their meds at
almost no cost and no red tape for the provider. One such program
is “PAP” found at
www.diabetes-meds.com
Also:
Diabetes
Care November 1999
–“The
immediate feedback of HbA1c results at the time of patient
encounters resulted in a significant improvement of glycemic
control at 6-month follow-up and persisted for the 12-month study
–“Availability of rapid HbA1c determinations appears to facilitate
diabetes management. The more favorable HbA1c profile in the rapid
HbA1c group occurs independently of the decision to intensify
therapy, suggesting the involvement of other factors such as
enhanced provider and/or patient motivation.”
Now you can have an instant A1c
test, for home and office use
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