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#2
White
Blood Cell Count Predicts Diabetes
New
Tool to Diagnosis possible development of type 2 diabetes and
worsening of insulin sensitivity.
A
high white blood cell count (WBC) predicts the development of type
2 diabetes, say researchers.
The
researchers measured the WBC in 352 nondiabetic Pima Indians (215
men; 137 women) who were characterized by body composition,
glucose tolerance, insulin action and acute insulin secretary
response. Chronic
low-grade inflammation may be involved in the pathogenesis of
insulin resistance and type 2 diabetes. We examined whether a
high white blood cell count (WBC), a marker of inflammation, predicts
a worsening of insulin action, insulin secretory function, and
the development of type 2 diabetes in Pima Indians.
Among
the 272 individuals with normal glucose tolerance at baseline, 54
developed diabetes over the follow-up. In a multivariate analysis
that accounted for age and sex, percentage of body fat and Insulin
action was independently associated with WBC.
A
high WBC value predicted diabetes (relative hazard 90th
vs. 10th percentiles [95%CI] of 2.7 [1.3–5.4], P
= 0.007) when adjusted for age and sex. The predictive
effect of WBC persisted after additional adjustment for
established predictors of diabetes, i.e., percent body
fat, M, and AIR (relative hazard 2.6 [1.1–6.2], P
= 0.03). After adjustment for follow-up duration, a high WBC
at baseline was associated with a subsequent worsening of M
(P = 0.003), but not a worsening of AIR. A high WBC
predicts a worsening of insulin action and the
development of type 2 diabetes in Pima Indians. These
findings are consistent with the hypothesis that a
chronic activation of the immune system may play a role
in the pathogenesis of type 2 diabetes.
Reference:
Vozarova B et al. High white blood cell count is associated
with a worsening of insulin sensitivity and predicts the
development of type 2 diabetes. Diabetes 2002; 51: 455-61.
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Chesapeake
Hospital and the Anodyne Therapy System
The
wound center at Chesapeake Hospital shared one of their case
studies with us Click
here to view the results
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