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Item
#12
Sex
Differences in Risk Factors for Incidence Type 2 Diabetes
Men
found to be more prone to diabetes
OBJECTIVE:
To examine sex-specific associations between cardiovascular risk
factors, a parental history of diabetes, and type 2 diabetes
mellitus (DM). METHODS: The study is based on 3052 men and 3114
women (aged 35 to 74 years) who participated in one of the 3
MONICA (Monitoring of Trends and Determinants in Cardiovascular
Disease) Augsburg surveys between 1984 and 1995, which were free
of DM at baseline and returned a follow-up questionnaire in 1998.
Sex-specific hazard ratios (HRs) were estimated from Cox
proportional hazard models.
RESULTS:
A total of 128 cases of incident DM among men and 85 cases among
women were registered during the follow-up period. The
age-standardized incidence rate was 5.8 per 1000 person-years for
men and 4.0 per 1000 person-years for women. In multivariable
survival analyses, age, body mass index, and a positive parental
history of diabetes were important independent risk factors for DM
in both sexes. High-density lipoprotein cholesterol level was
inversely associated with DM in men and women. For other risk
factors, sex-related differences were observed. Systolic blood
pressure (HR per 10 mm Hg increase, 1.16), regular smoking (HR,
1.75), and high daily alcohol intake (HR, 1.95) predicted the
development of DM in men only, whereas uric acid (HR per 1 mmol/L
increase, 2.05) and physical inactivity during leisure time (HR,
1.80) were associated with diabetes development in women only.
CONCLUSIONS:
In men and women, most variables predicting future diabetes in the
present study are also known to be important risk factors for
cardiovascular disease and arteriosclerosis. However, there are
sex-related dissimilarities that seem to be involved in disease
development. Arch
Intern Med 2002 Jan 14;162(1):82-9
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